I alternate between CLIP STUDIO PAINT Pro+EX on desktop and Procreate on the iPad Pro (12.9). I have used Photoshop as well but do not prefer it. I also used SAI for a good while before buying CSP.
Besides my iPad, I use a 2017 Wacom Intuos Pro medium.
Layer modes! My favorites are add glow and glow dodge in CSP. There is a lot of brain work and experimentation going on as well.
As long as it is SFW. Sorry they are so hard to draw lol